In an ever-changing landscape of medical challenges, the issue of Antimicrobial Resistance (AMR) remains a critical concern. The need for concerted efforts to combat AMR has never been more pressing, and that is why we are proud to announce the Second International Conference on Combating Antimicrobial Resistance, CAMR-2024, hosted by the Department of Microbiology, Aarupadai Veedu Medical College and Hospital. Building on the success of CAMR-2024, this conference is dedicated to the theme of “Clinical Challenges and Solutions in Antimicrobial Resistance.” The global health community must unite to confront this escalating crisis.